Decomposing Multilocus Linkage Disequilibrium
نویسندگان
چکیده
منابع مشابه
Decomposing multilocus linkage disequilibrium.
We present a mathematically precise formulation of total linkage disequilibrium between multiple loci as the deviation from probabilistic independence and provide explicit formulas for all higher-order terms of linkage disequilibrium, thereby combining J. Dausset et al.'s 1978 definition of linkage disequilibrium with H. Geiringer's 1944 approach. We recursively decompose higher-order linkage d...
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Linkage disequilibrium (LD) in the human genome, often measured as pairwise correlation between adjacent markers, shows substantial spatial heterogeneity. Congruent with these results, studies have found that certain regions of the genome have far less haplotype diversity than expected if the alleles at multiple markers were independent, while other sets of adjacent markers behave almost indepe...
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Linkage disequilibrium (LD) of genetic loci is routinely estimated and graphically illustrated in genetic association studies. It has been suggested that the information in LD is also useful for association mapping and genetic association can be detected by comparing LD patterns between cases and controls. Here, we extend this idea to analyze case-parents data by comparing LD patterns between t...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.166.3.1581